CIGENE - Centre for Integrative Genetics, and
Department of Mathematical Sciences and Technology
Norwegian University of Life Sciences, N-1430 As, Norway
Arcady Ponosov
Abstract:
This paper suggests a mathematical framework to study gene regulatory
networks with time-delay effects, which is based on delay
differential equations. An essential feature of the gene regulatory
networks is their ``almost Boolean'' structure, where the dynamics is
governed by sigmoid-type nonlinearities which are close to the step
functions. This is due to the fact that genes are only activated if
certain concentrations are close to the respective threshold values.
Thus, any mathematical model describing such networks faces a
problem of how to study the dynamics in the vicinity of the
thresholds. The paper presents some properties of gene regulatory
networks with delay in comparison with the non-delay model. A method
of localizing stationary points near the thresholds in the presence
of delays is offered. The basic technical tool, which is
systematically applied in the paper, is a special modification of
the well-known ``linear chain trick". The results are illustrated by
a number of examples.
Published April 20, 2005.
Math Subject Classifications: 34K60, 92D10.
Key Words: Gene regulation; delay equations; stability.
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Arcady Ponosov CIGENE - Centre for Integrative Genetics, and Department of Mathematical Sciences and Technology Norwegian University of Life Sciences, N-1430 As, Norway |
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