\documentclass[reqno]{amsart}
\usepackage{hyperref}

\AtBeginDocument{{\noindent\small
\emph{Electronic Journal of Differential Equations},
Vol. 2017 (2017), No. 152, pp. 1--15.\newline
ISSN: 1072-6691. URL: http://ejde.math.txstate.edu or http://ejde.math.unt.edu}
\thanks{\copyright 2017 Texas State University.}
\vspace{8mm}}

\begin{document}
\title[\hfilneg EJDE-2017/152\hfil Finite time blow-up of solutions]
{Finite time blow-up of solutions for a nonlinear system
of fractional differential equations}

\author[A. Mennouni, A. Youkana \hfil EJDE-2017/152\hfilneg]
{Abdelaziz Mennouni, Abderrahmane Youkana}

\address{Abdelaziz Mennouni \newline
Department of Mathematics,
University of Batna 2, 05078 Batna, Algeria}
\email{aziz.mennouni@yahoo.fr}

\address{Abderrahmane Youkana \newline
Department of Mathematics,
University of Batna 2, 05078 Batna, Algeria}
\email{abder.youkana@yahoo.fr}


\dedicatory{Communicated by Mokhtar Kirane}

\thanks{Submitted March 14, 2017. Published June 25, 2017.}
\subjclass[2010]{33E12, 34K37}
\keywords{Fractional differential equation; Caputo fractional derivative;
\hfill\break\indent blow-up in finite time}

\begin{abstract}
 In this article we study the blow-up in finite time of solutions for
 the  Cauchy problem of fractional ordinary  equations
 \begin{gather*}
 u_{t} +a_1\,^{c}D_{0_{+}}^{\alpha_1} u +a_2\,^{c}D_{0_{+}}^{\alpha_2} u+\dots
 +a_{n}\,^{c}D_{0_{+}}^{\alpha_n} u
 =\int_0^{t} \frac{(t-s)^{-\gamma_1}}{ \Gamma(1-\gamma_1) }f(u(s),v(s))ds,\\
 v_{t} +b_1\,^{c}D_{0_{+}}^{\beta_1} v+ b_2\,^{c}D_{0_{+}}^{\beta_2} v+\dots
 +b_{n}\,^{c}D_{0_{+}}^{\beta_n} v
 = \int_0^{t} \frac{(t-s)^{-\gamma_2}}{ \Gamma(1-\gamma_2) }g(u(s),v(s))ds,
  \end{gather*}
 for $t>0$, where the derivatives are Caputo fractional derivatives of order
 $\alpha_i, \beta_i$,  and $f$ and $g$ are two continuously differentiable
 functions with polynomial growth.
 First, we  prove the existence and uniqueness of local  solutions
 for the above system  supplemented with initial conditions,
 then we establish that they blow-up in finite time.
\end{abstract}

\maketitle
\numberwithin{equation}{section}
\newtheorem{theorem}{Theorem}[section]
\allowdisplaybreaks

\section{Introduction}

In this work, we study the  system of ordinary fractional differential equations
\begin{equation} \label{11}
\begin{aligned}
&u_{t} +a_1\,^{c}D_{0_{+}}^{\alpha_1} u +a_2\,^{c}D_{0_{+}}^{\alpha_2} u+\dots
+a_{n}\,^{c}D_{0_{+}}^{\alpha_n} u  \\
&=\int_0^{t} \frac{(t-s)^{-\gamma_1}}{ \Gamma(1-\gamma_1) }f(u(s),v(s))ds,\\
&v_{t} +b_1\,^{c}D_{0_{+}}^{\beta_1} v+ b_2\,^{c}D_{0_{+}}^{\beta_2} v+\dots
+b_{n}\,^{c}D_{0_{+}}^{\beta_n} v \\
&= \int_0^{t} \frac{(t-s)^{-\gamma_2}}{ \Gamma(1-\gamma_2) }g(u(s),v(s))ds, 
  \end{aligned}
\end{equation}
for $t>0$,  with initial data
 \begin{equation}
 \label{12}   u(0)=u_0>0,\quad v(0)=v_0>0,
 \end{equation}
and where $ 0<\alpha_i <1$, $ 0< \beta_i <1$, $i=1,\dots,n$,
 $ 0<\gamma_j <1 $,  $ j=1,2$,  $f$ and $g$ are two real continuous
differentiable functions defined on
 $ \mathbb{R}\times \mathbb{R} $,  $ a_{i}$,  $b_{i}$ $i=1,\dots,n$  are
positive constants, $ \Gamma$ is the Euler function and
$ D_{0^{+}}^{\alpha_i}$,  $  D_{0^{+}}^{\beta_i}$, $i=1,\dots,n$, are
  Caputo fractional derivatives.

  In recent years, fractional differential equations have played an important
   role in the study of models for many phenomena in various  fields of physics,
biology   and engineering, such as aerodynamics, viscoelasticity, control of
dynamic systems, electrochemistry, porous media, etc
(see \cite{Bushell,CapDong,Hilfer, Samko}  and the references therein);
their study attracted the attention of many researchers (see for instance
\cite{KirKa, KirOlmRob, Liu, Mydlar} and the references therein).
  In addition, a particular attention was given for the study of the local
existence and uniqueness of solutions for these systems and their properties
like the blow-up in finite time, the global existence, the asymptotic behavior,
etc. (see \cite{CapDong, KirOlmRob,Liu, Mydlar}).

In \cite{KirMal}, the profile of the blowing-up  solutions has been investigated
 for the following nonlinear nonlocal system
\begin{gather*}
 u_{t}(t)+ D_{0_{+}}^{\alpha}(u-u_0)(t)=|v(t)|^q ,\quad t>0, \; q >1,\\
v_{t}(t)+ D_{0_{+}}^{\beta}(v-v_0)(t)=|u(t)|^p, \quad t>0,\; p >1,\\
u(0)=u_0>0, \quad v(0)=v_0>0,
   \end{gather*}
as well as for  solutions of  systems  obtained by dropping either
the usual derivatives or the fractional derivatives.

In \cite{KadKir}, some results on the blow-up of the solutions and  lower
 bounds of the maximal time have been established for the system
\begin{gather*}
  u_{t}(t)+\rho D_{0_{+}}^{\alpha}(u-u_0)(t)=e^{v(t)} ,\quad t>0, \; \rho >0,\\
v_{t}(t)+\sigma D_{0_{+}}^{\beta}(v-v_0)(t)=e^{u(t)}, \quad t>0,\; \sigma >0,\\
u(0)=u_0>0,\quad v(0)=v_0>0,
\end{gather*}
and the subsystem obtained by dropping the usual derivatives.

   In the spirit of the interesting works  \cite{Furati, KadKir, KirMal},
we prove that the non global existence of solutions  to \eqref{11}-\eqref{12}
holds for polynomial nonlinearities.
 For the existence of  solutions for the system \eqref{11}-\eqref{12},
we will use the Schauder theorem.

Our paper is organized as follows:
In Section 2, we  give some preliminary results for fractional derivatives.
In Section 3, we will  prove  the local  existence and uniqueness of the solutions.
 In Section 4, we will state and prove our main result on the blow- up in
finite time of solutions for system \eqref{11}-\eqref{12}.

\section{Preliminaries and mathematical background}

For the convenience of the reader, we shall recall some known results concerning
 fractional integrals and derivatives that will be useful in the sequel.

The Riemann-Liouville fractional integral of order $0<\alpha<1$ with lower
limit $0$ is defined for a locally integrable function
$ \varphi : \mathbb{R}_{+} \to \mathbb{R} $ by
\[
J_{0_{+}}^{\alpha}\varphi(t)=\frac{1}{\Gamma(\alpha)}
\int_0^{t}\frac{\varphi(s)}{(t-s)^{1-\alpha}}ds,\quad t>0,
\]
where $\Gamma$ is the Euler Gamma function.

The left-handed and right-handed Riemann-Liouville fractional derivatives
of order $ \alpha$ with $0<\alpha<1$ of a continuous function $\psi(t)$ are
defined by
\[
D^{\alpha}_{0_{+}}\psi(t)=\frac{1}{\Gamma(1-\alpha)}\frac{d}{dt}
\int_0^{t}\frac{\psi(s)}{(t-s)^{\alpha}}ds,\quad t>0,
\]
and
\[
D^{\alpha}_{T^{-}}\psi(t)=-\frac{1}{\Gamma(1-\alpha)}\frac{d}{dt}
\int_{t}^{T}\frac{\psi(s)}{(s-t)^{\alpha}}ds,\quad t>0,
\]
respectively.
One can see that
$$
\frac{d}{dt}J_{0^+}^{1-\alpha}\psi(t)=D_{0{+}}^{\alpha}\psi(t),\quad t>0.
$$
The integration by parts formula (see \cite{Samko}) in $ [0,T]$ reads
\begin{equation*}
\int_0^{T} h(t) D^{\alpha}_{0_{+}}k(t) dt
= \int_0^{T} (D^{\alpha}_{T_{-}} h(t))k(t)dt,
\end{equation*}
for  functions $h, k$ in $C([0,T]) $  such that $D_{0^{+}}^{\alpha} k$ and
$ D_{T^{-}}^{\alpha} h$ are continuous.

The Caputo fractional derivative of order $0<\alpha<1$ of an  absolutely
continuous function $\phi(t)$ of order $ 0 < \alpha < 1$  is defined by
\[
^{c}D^{\alpha}_{0_{+}} \phi(t) = J^{1-\alpha}_{0_{+}}
\frac{d}{dt} \phi(t)=\frac{1}{\Gamma(1-\alpha)}
\int_0^{t}(s-t)^{-\alpha} \phi'(s) ds.
\]

The relation between the Riemann-Liouville and the Caputo fractional derivatives
for an absolutely continuous function $\phi(t)$ is  given by
\begin{equation*}
^{c}D^{\alpha}_{0_{+}} \phi(t) = D^{\alpha}_{0_{+}}(\phi(t)-\phi(0)),
\quad  0 <\alpha <1.
\end{equation*}


\section{Existence and uniqueness of solutions}

In this section, we deal with the existence and uniqueness of local solutions
for  problem \eqref{11}-\eqref{12}. We say that
 $(u,v)$ is a local classical solution if it satisfies
equations \eqref{11}-\eqref{12} on some interval $ (0,T^*)$.
 Our main result in this section reads as follows.

 \begin{theorem} \label{thm3.1}
Assume that the functions $f$ and $g$ are of class
$C^{1}(\mathbb{R}\times\mathbb{R},\mathbb{R})$.
Then  system  \eqref{11}-\eqref{12} admits a unique local classical
solution on a maximal interval $( 0, T_{\rm max})$ with the alternative:
 either\ $T_{\rm max}=+\infty$  and the solution is global;
 or
 $$
T_{\rm max}<+\infty \quad\text{and}\quad
\lim_ {t\to T_{\rm max}}(| u(t)|+| v(t)|)=+\infty.
$$
\end{theorem}

\begin{proof}
For the sake of completeness, we give the proof of the existence
of solutions of \eqref{11}-\eqref{12}.
Let $ k>0$ be a positive constant   and
\begin{equation}\label{31}
 h:=  \min\{  \sigma_1,\ \sigma_2\}>0,
\end{equation}
where
\begin{gather*}
\sigma_1:= \min\Big\{ \min_{1\leq i\leq n}
\Big(  \frac{1}{2n^2\bar{a}\max_{1\leq i \leq n}
( \frac{1}{\Gamma(2-\alpha_{i})})}\Big)^{\frac{1}{1-\alpha_{i}}},
\Big( \frac{k\Gamma(2-\gamma_1)}{2M}\Big) ^\frac{1}{1-\gamma_1} \Big\}, \\
\sigma_2:= \min\Big\{ \min_{1\leq i\leq n}
\Big( \frac{1}{2n^2\bar{b}\max_{1\leq i \leq n} \frac{1}{\Gamma(2-\beta_{i})})}
 \Big)^{\frac{1}{1-\beta_{i}}}, \Big( \frac{k\Gamma(2-\gamma_2)}{2M}\Big)
^\frac{1}{1-\gamma_2}\Big\}, \\
\bar{a}=\max_{1\leq i\leq n}\{ a_i\},\quad\bar{b} =\max_{1\leq i\leq n}\{ b_i\}.
\end{gather*}
Let  $ C([0,h]) \times  C([0,h])$ be the space of all continuous
functions $(\chi,\psi)$ on $ [0,h] $  equipped with the norm
$$
\| (\chi,\psi) \|_{\infty}=
  \max ( \| \chi \|_{\infty},\;  \| \psi \|_{\infty}),
$$
where
$$
\|\chi\|_{\infty}=\max_{0\leq t\leq h}| \chi(t)|,\quad
\|\psi\|_{\infty}=\max_{0\leq t\leq h}| \psi(t)|.
$$
For simplicity, we assume
 $ \alpha_1\leq \alpha_2 \leq\dots \leq \alpha_n$  and
 $ \beta_1\leq \beta_2 \leq\dots \leq \beta_n$.

Now, in order to prove the existence of solutions for problem \eqref{11}-\eqref{12},
we rewrite it as a system of integral equations in $ C([0,h])\times C([0,h])$,
 \begin{equation} \label{32}
\begin{aligned}
  x(t)& =-a_1J^{1-\alpha_1}_{0_{+}}x(t)-a_2J^{1-\alpha_2}_{0_{+}}x(t)
-\dots -a_{n}J^{1-\alpha_n}_{0_{+}}x(t) + J_{0^{+}}^{1-\gamma_1} f (u_0 \\
&\quad +\int_0^{t} x(s)ds, v_0+\int_0^{t} y(s)ds) \\
  y(t) &=-b_1J^{1-\beta_1}_{0_{+}}y(t)-b_2J^{1-\beta_2}_{0_{+}}y(t)
-\dots -b_{n}J^{1-\beta_n}_{0_{+}}y(t)+J_{0^{+}}^{1-\gamma_2} g (u_0 \\
&\quad+\int_0^{t} x(s)ds, v_0+\int_0^{t} y(s)ds),
  \end{aligned}
\end{equation}
via the transformation
\[
  u(t)=u_0+\int_0^t x(s)ds,\quad v(t)=v_0+\int_0^t y(s)ds,
\]
and the relation $^{c}D_{0^+}^{\alpha}\psi(t)=J_{0^{+}}^{1-\alpha}\frac{d}{dt}\psi(t)$,
and we shall  prove the existence of local solutions for \eqref{32}.

So, let us define the operator
 $A :  C([0,h]) \times  C([0,h])\to C([0,h])\times  C([0,h]) $ by
$$
A(x,y)= (A_1(x,y),\ A_2(x,y)),
$$
where
\begin{equation} \label{33}
\begin{aligned}
   A_1(x(t),y(t))
&=-\sum_{i=1}^{n}a_{i}J^{1-\alpha_i}_{0_{+}}x(t)\\
&\quad +J_{0^{+}}^{1-\gamma_1} f \Big(u_0+\int_0^{t} x(s)ds, v_0+\int_0^{t} y(s)ds\Big),
  \\
A_2(x(t),y(t))&= -\sum_{i=1}^{n}b_{i}J^{1-\beta_i}_{0_{+}}y(t)\\
&\quad +J_{0^{+}}^{1-\gamma_2} g \Big(u_0+\int_0^{t} x(s)ds, v_0+\int_0^{t} y(s)ds\Big).
 \end{aligned}
 \end{equation}
Let us define the  set
$$
D :=\big\{ (x,y) \in C([0,h]) \times C([0,h]),\;  \| (x,y) \|_{\infty}=
  \sup( \| x \|_{\infty},\; \| y \|_{\infty})
  \leq k   \},
$$
as a domain of the operator $A$,  which is a convex, bounded, and closed
subset of the Banach space $ C([0,h])\times C([0,h])$.
  Since  $f$ and $g$ are continuously  differentiable on
$ [u_0-kh,u_0+kh]\times [v_0-kh,v_0+kh]$, there exists a positive constant
$ M$ such that for any $ t$ in $ [0,h]$ and any $(x,y)$ in $D$,
  \begin{gather} \label{34}
\big| f(u_0+\int_0^t x(s)ds,\ v_0+\int_0^t y(s))ds \big| \leq M, \\
  \label{35}
\big| g((u_0+\int_0^t x(s)ds,\ v_0+\int_0^t y(s))ds \big| \leq M,
  \end{gather}
and  for any $(u_j,v_j)$  in $ [u_0-kh,u_0+kh]\times [v_0-kh,v_0+kh]$,
 $j=1,2,$  and  any $t$ in $ [0,h]$,  there exist two positive  constants
$L_1$ and $L_2$ depending on $u_0, v_0, k, h $  and on $f$ and $g$
respectively such that
 \begin{gather}  \label{36}
| f(u_1(t),v_1(t))-f(u_2(t),v_2(t))|
\leq L_1\| (u_1(t)-u_2(t),v_1(t)-v_2(t))\|,\\
   \label{37}
| g(u_1(t),v_1(t))-g(u_2(t),v_2(t))|
\leq L_2\| (u_1(t)-u_2(t),u_1(t)-u_2(t))\|,
\end{gather}
where $\| (u_1(t)-u_2(t),v_1(t)-v_2(t))\|$=$| u_1(t)-u_2(t)|+| v_1(t)-v_2(t)|$.

Now, by using \eqref{31} and \eqref{36} and \eqref{37},  for all
 $z_1=( x_1,y_1)\in D$ and $z_2=(x_2,y_2) \in D$ satisfying
$ \| z_1-z_2\|_\infty\ <\delta$,
where $\delta$ is a positive constant which will be defined later, we obtain
\begin{equation}
\begin{aligned}
&\|  A_1(z_1)-A_1(z_2) \|_{\infty} \\
&= \sup_{ 0\leq t \leq h}  |   -\sum_{i=1}^{n}  a_{i}J^{1-\alpha_i}_{0_{+}}x_1(t)
+  J_{0^{+}}^{1-\gamma_1} f(u_0 + \int_0^{t} x_1(s)ds,\ v_0
 + \int_0^{t} y_1(s)ds) \\
&\quad + \sum_{i=1}^{n}a_{i}J^{1-\alpha_i}_{0_{+}}x_2(t)
 -   J_{0^{+}}^{1-\gamma_1}f(u_0 + \int_0^{t} x_2(s)ds,\ v_0
 + \int_0^{t} y_2(s)\,ds) \ |  \\
&\leq \sup_{ 0\leq t \leq h}  |  -\sum_{i=1}^{n}  a_{i}J^{1-\alpha_i}_{0_{+}}
 (x_1(t)-x_2(t)) \\
&\quad +   J_{0^{+}}^{1-\gamma_1}\{ f(u_0 + \int_0^{t} x_1(s)ds, v_0
 + \int_0^{t} y_1(s) ds)  \\
&\quad - f(u_0 + \int_0^{t} x_2(s)ds, v_0 + \int_0^{t} y_2(s)ds)\}| \\
&\leq \sum_{i=1}^{n} \frac{a_{i}}{\Gamma(1-\alpha_i)} \int_0^{h}
 (t-s)^{-\alpha_i} \| z_1-z_2\|_\infty ds
  +  \frac{L_1}{\Gamma(2-\gamma_1)}  h^{2-\gamma_1}\| z_1-z_2\|_\infty \\
 &\leq  \Big( n\bar{a}\max_{1\leq\ i \leq n}\{\frac{1}{\Gamma(2-\alpha_i)}\}
 \sum_{i=1}^{n}{h^{1-\alpha_i}  }+ \frac{L_1}{\Gamma(2-\gamma_1)} \ h^{2-\gamma_1}
 \Big)  \delta,
\end{aligned}
\end{equation}
and in the same way, we obtain
\begin{equation}
\|  A_2(z_1)-A_2(z_2) \|_{\infty}\leq
\Big( n\bar{b}\max_{1\leq\ i \leq n}\{\frac{1}{\Gamma(2-\beta_i)}\}
\sum_{i=1}^{n}{h^{1-\beta_i}  }+\frac{L_2}{\Gamma(2-\gamma_2)}
h^{2-\gamma_2}\Big)\delta.
\end{equation}
Now, given an $\varepsilon >0$, pick
 $\delta = \min\big\{\frac{\varepsilon}{ \omega_1},\frac{\varepsilon}{ \omega_2 }
 \big\}$,
where
\begin{gather*}
\omega_1 : =  n\bar{a}\max_{1\leq\ i \leq n}
\big\{\frac{1}{\Gamma(2-\alpha_i)}\big\} \sum_{i=1}^{n}{h_{i}^{1-\alpha_i}}
+  \frac{L_1}{\Gamma(2-\gamma_1)}  h^{2-\gamma_1}\, , \\
\omega_2 : = n\bar{b}\max_{1\leq\ i \leq n}
\big\{\frac{1}{\Gamma(2-\beta_i)}\big\} \sum_{i=1}^{n}{h_{i}^{1-\beta_i}}
+\frac{L_2}{\Gamma(2-\gamma_2)}  h^{2-\gamma_2}\,.
\end{gather*}
One can see that
$\|  A(z_1)-A(z_2) \|_{\infty}< \varepsilon$,
consequently, $ A $ is a continuous operator on $D $.

Next, from \eqref{33}, \eqref{34}, \eqref{35} and \eqref{31}, for all
$z= (x,y) \in D $  we have
\begin{equation}\label{310}
\begin{aligned}
&\| A_1(z) \|_{\infty}\\
& \leq  \sup_{0\leq t\leq h}
 \Big|  \sum_{i=1}^{n} \frac{ a_{i}}{\Gamma(1-\alpha_i)}\int_0^{t}
 (t-s)^{-\alpha_i}  x(s) \,ds  \\
&\quad + \frac{1}{\Gamma(1-\gamma_1)}\int_0^{t} (t-s)^{-\gamma_1} f( u_0
 +\int_0^{t}x(s)ds,v_0+\int_0^{t}y(s))ds   \Big|  \\
&\leq  \sum_{i=1}^{n} \frac{a_{i}}{\Gamma(1-\alpha_i)} \| z \|_\infty
 \int_0^{h} (t-s)^{-\alpha_i} ds
 + \frac{1}{\Gamma(1-\gamma_1)}\int_0^{t} (t-s)^{-\gamma_1} M\,ds    \\
&\leq  nk\bar{a} \max_{1\leq i \leq n}\big\{ \frac{1}{\Gamma(2-\alpha_i)}\big\}
 \sum_{i=1}^{n} {h^{1-\alpha_i}} + \frac{1}{\Gamma(2-\gamma_1)}Mh^{1-\gamma_1}
\leq k.
\end{aligned}
\end{equation}
and
\begin{equation}\label{311}
\begin{aligned}
&\| A_2(z) \|_{\infty}\\
&\leq  \sup_{0 \leq t \leq h } \big|  \sum_{i=1}^{n}
 \frac{ b_{i}}{\Gamma(1-\beta_i)}\int_0^{t} (t-s)^{-\beta_i}  x(s) \,ds
     +  \frac{1}{\Gamma(2-\gamma_2)}Mh^{1-\gamma_1}   \big|    \\
&\leq  \sum_{i=1}^{n} \frac{a_{i}}{\Gamma(1-\beta_i)} \| z \|_{\infty}
 \int_0^{h} (t-s)^{-\beta_i} ds + \frac{1}{\Gamma(2-\gamma_2)}Mh^{1-\gamma_2}  \\
&\leq nk\bar{b} \max_{1\leq i \leq n}\big\{ \frac{1}{\Gamma(2-\beta_i)}\Big\}
 \sum_{i=1}^{n} {h^{1-\beta_i}} + \frac{1}{\Gamma(2-\gamma_2)}Mh^{1-\gamma_2}
\leq  k.
\end{aligned}
\end{equation}
Inequalities \eqref{310} and \eqref{311} assert that  $ A(D) \subset D$.
Thus, the set $ A(D )$ is  uniformly bounded.
Now, for all $ 0\leq t_1\leq t_2\leq h $ with $ | t_1-t_2 | < \eta$, and  all
$ z=(x,y) \in C([0,h])\times C([0,h]) $,  from \eqref{36}  we have
\begin{align}
&| A_1( \ z(t_1))-A_1( \ z(t_2) \ ) |  \nonumber \\
&= \Big|  -\sum_{i=1}^{n}\frac{a_{i}}{\Gamma(1-\alpha_i)}
 \int_0^{t_1} (t_1-s)^{-\alpha_i}x(s)ds  \nonumber  \\
&\quad + \frac{1}{\Gamma(1-\gamma_1)}\int_0^{t_1}(t_1-s)^{-\gamma_1}
 f(  u_0+\int_0^{s}x(\tau)d\tau,v_0+\int_0^{s}y(\tau)d\tau)ds  \nonumber  \\
&\quad + \sum_{i=1}^{n} \frac{a_{i}}{\Gamma(1-\alpha_i)}\int_0^{t2}
 (t_2-s)^{-\alpha_i}x(s)ds  \nonumber \\
&\quad - \frac{1}{\Gamma(1-\gamma_1)}\int_0^{t_2}(t_2-s)^{-\gamma_1}f(u_0
 +\int_0^{s}x(\tau)d\tau, \  v_0+\int_0^{s}y(\tau)d\tau) ds\Big|   \nonumber \\
&\leq  \sum_{i=1}^{n}\frac{ a_{i}}{\Gamma(1-\alpha_i)} \int_0^{t_1}
 \left(  (t_1-s )^{-\alpha_i}-(t_2-s)^{-\alpha_i}\right) |  x(s) | ds \nonumber \\
&\quad + \sum_{i=1}^{n}\frac{a_{i}}{\Gamma(1-\alpha_i)}
 \int_{t_1}^{t_2} (t_2-s)^{-\alpha_i} | x(s) | ds  \nonumber \\
&\quad + \frac{1}{\Gamma(1-\gamma_1)} \int_0^{t_1}
 \left(  (t_1-s )^{-\gamma_1}-(t_2-s)^{-\gamma_1} \right) \nonumber \\
&\quad\times  \Big| f(u_0
 +\int_0^{s}x(\tau)d\tau,v_0+\int_0^{s}y(\tau)d\tau)\Big| ds  \nonumber \\
&\quad + \frac{1}{\Gamma(1-\gamma_1)}\int_{t_1}^{t_2}(t_2-s)^{-\gamma_1}
\Big| f( u_0+\int_0^{s}x(\tau)d\tau,  v_0+\int_0^{s}y(\tau)d\tau) \Big| ds \nonumber \\
&\leq  k\bar{a}\sum_{i=1}^{n}\frac{1}{\Gamma(2-\alpha_i)}
 (t_2-t_1) ^{1-\alpha_i}+\frac{2M}{\Gamma(2-\gamma_1)}
 (t_2-t_1)  ^{1-\gamma_1}. \label{312}
\end{align}
Similarly, we obtain
\begin{equation}\label{313}
\begin{aligned}
&| A_2( z(t_1) ) - A_2(  z(t_2) ) |\\
&\leq k\bar{b}\sum_{i=1}^{n}\frac{1}{\Gamma(2-\beta_i)}
( t_2-t_1) ^{1-\beta_i}+\frac{2M}{\Gamma(2-\gamma_2)}
(t_2-t_1)  ^{1-\gamma_2}.
\end{aligned}
\end{equation}

From \eqref{312} and \eqref{313} it yields that  $ A(D) $ is equicontinuous,
and so by using Arzela-Ascoli theorem, we find that  $ A(D) $  is  relatively
compact in $ C([0,h])\times C([0,h])$.

Finally, by  Schauder theorem, we conclude that the operator $ A $ has at
least one fixed point,  this means that the system of integral equations
\eqref{32} has at least one local continuous solution $(x,y) $ defined on
 $ [0,h] $.
Now, since  for all $t\in [0,h]$,
\begin{equation} \label{314}
u(t)= u_0 +\int_0^{t} x(s)ds, \quad
v(t)= v_0 + \int_0^{t} y(s)ds,
\end{equation}
where $x $ and $y$ are solutions of  system \eqref{32} of integral equations,
it follows that
$ u'(t)=x(t)$, $v'(t)=y(t)$  for any $t$  in  $(0,h)$.

Using the definition of  Caputo fractional derivative, we find for
all $t$  in $ (0,h)$,
\begin{equation} \label{315 }
\begin{aligned}
{}^cD^{{\alpha}_{i}}_{0_+} u(t)= J^{1-\alpha_i}_{0_+} x(t)
= \frac{1}{\Gamma(1-\alpha_i)} \int_0^T (t-s)^{-\alpha_i} x(s) \,ds, \quad
i=1,\dots,n, \\
{}^cD^{{\beta}_{i}}_{0_+} v(t)\ = J^{1-\beta_i}_{0_+}
y(t) = \frac{1}{\Gamma(1-\beta_i)} \int_0^T (t-s)^{-\beta_i} y(s) \,ds, \quad
i=1,\dots,n.
\end{aligned}
\end{equation}
Combining  \eqref{314}, \eqref{315 } and \eqref{32}, for all $t$ in $(0,h)$
we obtain
\begin{equation}
\begin{gathered}
u'(t)+\sum_{i=1}^{n}a_iJ^{1-\alpha_i}_{0_+}\frac{du(t)}{dt}
= J_{0_+}^{1-\gamma_1} f(u(s),v(s))  \\
v'(t)+\sum_{i=1}^{n} b_iJ^{1-\beta_i}_{0_+}\frac{dv(t)}{dt}
= J_{0_+}^{1-\gamma_2}g(u(s),v(s)).
\end{gathered}
\end{equation}
Since $(u(0),v(0))=(u_0,v_0)$, we conclude that  $ (u,v)$ is a classical
solution for  \eqref{11}-\eqref{12} on $(0,h)$, and this solution may be extended
 (see \cite {Carvalho}) to a maximal interval  $( 0, T_{\rm max})$ with
the alternative:  either $T_{\rm max}=+\infty$  and the solution is global;
 or
 $$
T_{\rm max}<+\infty \quad \text{and} \quad
\lim_ {t\to T_{\rm max}}(| u(t)|+| v(t)|)=+\infty.
$$

Next, we shall prove  uniqueness.
Assume that the Cauchy problem \eqref{11}-\eqref{12} admits two classical
solutions $ (u_1,v_1) $ and $ (u_2,v_2)$ with the same initial data
$(u_0,v_0)$  on $ (0, T_{\rm max})$.
Observe that for all  $ t \in (0,\rho)$ with $\rho<T_{\rm max}$,  these
solutions satisfy the following equalities:
\begin{equation} \label{317}
\begin{gathered}
(u_1-u_2)_{t} +\sum_{i=1}^{n} a_{i}D^{\alpha_i}_{0+}(u_1-u_2)
 = J_{0^{+}}^{1-\gamma_1}(f (u_1,v_1)-f(u_2,v_2)),\\
(v_1-v_2)_{t} +\sum_{i=1}^{n}b_{i}D^{\beta_i}_{0+}(v_1-v_2)
= J_{0^{+}}^{1-\gamma_2}( g (u_1,v_1)-g(u_2,v_2)).
\end{gathered}
\end{equation}
Integrating \eqref{317} over ${(0,t)}$  yields
\begin{equation} \label{318}
\begin{aligned}
&(u_1-u_2)(t) + \int_0^{t} \sum_{i=1}^{n} a_i  D^{\alpha_i}_{0_+}(u_1-u_2)(s)) \,ds\\
&=\int_0^{t} J_{0^{+}}^{1-\gamma_1}( f (u_1(s),v_1(s))-f(u_2(s),v_2(s)))ds\\
&(v_1-v_2)(t)+\int_0^{t} \sum_{i=1}^{n} b_i \ D^{\beta_i}_{0_+}(u_1-u_2)(s)) \,ds\\
&=\int_0^{t}  J_{0^{+}}^{1-\gamma_2}(g(u_1(s),v_1(s))-g(u_2(s),v_2(s)))ds.
\end{aligned}
\end{equation}

Let $\theta := \max\{ \alpha_1, \alpha_2,\dots, \alpha_{n},\beta_1, \beta_2,\dots,
 \beta_{n},   \gamma_1,  \gamma_2 \}$.
Using \eqref{318} and the fact that $f$ and $g$ are locally Lipshitz on
$ [0,h]$, thanks to \eqref{36} and \eqref{37},  for all $ t\in(0,\rho) $, we have
\begin{equation}\label{319}
\begin{aligned}
&| u_1(t)-u_2(t) |\\
&\leq  \int_0^{t} \Big(\sum_{i=1}^{n}\frac{a_{i}}{\Gamma(1-\alpha_i)}
(t-s)^{-\alpha_i} \\
&\quad + L_1\frac{(t-s)^{-\gamma_1}}{\Gamma(1-\gamma_1)}\Big)
\| u_1(s)-u_2(s), v_1(s)-v_2(s))\| ds 	 \\
&\leq \int_0^{t} \Big\{\sum_{i=1}^{n}\frac{a_{i}}{\Gamma(1-\alpha_i)}
 (t-s)^{\theta-\alpha_i}  \\
&\quad +\frac{L_1}{\Gamma(1-\gamma_1)}(t-s)^{\theta-\gamma_1}\}(t-s)^{-\theta}
\| u_1(s)-u_2(s),v_1(s)-v_2(s))\| ds 	\\
&\leq   d_1 \int_0^{t}  (t-s)^{-\theta} \| u_1(s)-u_2(s), v_1(s)-v_2(s))\| ds,
\end{aligned}
\end{equation}
where
 $$
d_1:=n\bar{a} \max_{1\leq i\leq n}
\big\{\frac{1}{\Gamma(1-\alpha_i)}\rho^{\theta-\alpha_i }\big\}
+\frac{L_1}{\Gamma(1-\gamma_1)}\rho^{\theta-\gamma_1},
$$
and  
\[
 \| u_1(t)-u_2(t),\ v_1(t)-v_2(t))\|= | u_1(t)-u_2(t)| + | v_1(t)-v_2(t)|.
\]
Similarly,
\begin{align}
| v_1(t)-v_2(t) |
&\leq \int_0^{t} \Big(\sum_{i=1}^{n}\frac{b_{i}}{\Gamma(1-\beta_i)}(t-s)^{-\beta_i}
\nonumber \\
&\quad+ L_2\frac{(t-s)^{-\gamma_2}}{\Gamma(1-\gamma_2)}\Big) \| u_1(s)-u_2(s),
 v_1(s)-v_2(s))\| ds 	\nonumber  \\
&\leq  \int_0^{t} \Big\{\sum_{i=1}^{n}\frac{b_{i}}{\Gamma(1-\beta_i)}
 (t-s)^{\theta-\beta_i} 
 + \frac{L_2}{\Gamma(1-\gamma_2)}(t-s)^{\theta-\gamma_2}\Big\} \nonumber \\
&\quad\times  (t-s)^{-\theta} \| u_1(s)-u_2(s),  v_1(s)-v_2(s))\| ds  \nonumber  \\
&\leq d_2\int_0^{t}(t-s)^{-\theta} \| u_1(s)-u_2(s), v_1(s)-v_2(s)\| ds,
\label{320}
\end{align}
where
 $$
d_2 :=n \bar{b}\max_{1\leq i\leq n}
\big\{\frac{1}{\Gamma(1-\beta_i)}\rho^{\theta-\beta_i}\big\}
+\frac{L_2}{\Gamma(1-\gamma_2)}\rho^{\theta-\gamma_2}.
$$
Then from \eqref{319} and \eqref{320}, we find
 \begin{equation}
\begin{aligned}
&\| (u_1(t)-u_2(t), v_1(t)-v_2(t)\| \\
&\leq  ( d_1+d_2) \int_0^{t}  (t-s)^{-\theta} \| u_1(s)-u_2(s), v_1(s)-v_2(s)\|
 \,ds  \quad  \forall t \in (0,\rho).
\end{aligned}
 \end{equation}
Finally using  Gronwall's inequality (see \cite[p. 6]{Henry}), we deduce
the uniqueness  and this completes the proof.
 \end{proof}

\section{Blow up results}
     This section is devoted to the blow up of solutions
of the system \eqref{11}-\eqref{12}  whenever the nonlinear terms satisfy
 certain growth conditions.
 Our main result reads as follows.

\begin{theorem} \label{thm4.1}
Assume that the assumptions of Theorem \ref{thm3.1} hold, and that the functions
$f$ and $g$ satisfy the growth conditions:
\begin{gather*}
  f(\xi,\eta) \geq a| \eta|^{q}, \quad \text{for all } \xi,\eta\in \mathbb{R}, \\
  g(\xi,\eta)\geq b | \xi |^{p},\quad  \text{for all }  \xi,\eta \in \mathbb{R},
 \end{gather*}
 for some positive constants $a$, $b$.
 Then for all  positive initial data, the  solution  of
 \eqref{11}-\eqref{12} blows up in a finite time.
\end{theorem}

\begin{proof}
We proceed by contradiction. We assume  that $ {T_{\rm max}=+\infty} $ and we
consider the function used in  \cite{Furati},
\begin{equation}\label{41}
\phi(t)= \begin{cases}
{T^{-\lambda}(T-t)^{\lambda}} & \text{for } t\in [0,T],\; \lambda\gg1,  \\
0 & \text{for }  t>T.
\end{cases}
\end{equation}
Then by multiplying  the first equation in \eqref{11} by $ \phi $ and
integrating over $ {(0,T)} $, we obtain
\begin{equation}\label{42}
\begin{aligned}
&\int_0^{T} u_{t}(t) \phi(t) dt+ \int_0^{T} \sum_{i=1}^{n} a_{i}
 ( D^{\alpha_i}_{0_{+}} (u(t)-u_0)) \phi(t) dt \\
&= \int_0^{T}( J_{0_+}^{1-\gamma_1}f(u(t),v(t))) \phi(t) dt.  
\end{aligned}
\end{equation}
Let
\[
\psi(t):=\int_0^{t} \phi(s)ds= -\frac{1
}{\lambda+1}T^{-\lambda}(T-t)^{\lambda+1}\quad t\in [0,T].
\]
Integrating by parts, and since $\psi(T)=0$, yields
\begin{equation}\label{43}
\begin{aligned}
\int_0^{T}( J_{0_+}^{1-\gamma_1}f(u(t),v(t))) \phi(t) dt
&=-\int_0^{T}\frac{d}{dt}( J_{0_+}^{1-\gamma_1}f(u(t),v(t)))\psi(t) dt  \\
&=-\int_0^{T}( D_{_{0_+}}^{\gamma_1}f(u(t),v(t)))\psi(t) dt \\
&=-\int_0^{T}( D_{T_{-}}^{\gamma_1}\psi (t))f((u(t),v(t))dt.
\end{aligned}
\end{equation}
Recall (see \cite{Furati}) the formulas
\[
D_{T^{-}}^{\gamma_j}\phi(t)=  C_{\lambda, \gamma_j}
T^{-\lambda}(T-t)^{\lambda-\gamma_j},\quad \text{where}
 C_{\lambda, \gamma_j}=\frac{\lambda\Gamma(\lambda-\gamma_j)}
{\Gamma(\lambda-2\gamma_j+1)},
\]
 and
\begin{equation}\label{44}
   D_{T^{-}}^{\gamma_j}\psi(t)
=  -\dfrac{1}{\lambda+1}C_{\lambda+1, \gamma_j} T^{-\lambda}(T-t)^{\lambda+1-\gamma_j}
 =-C_{\lambda,\gamma_j}'\phi(t)(T-t)^{1-\gamma_j},
 \end{equation}
for $j=1,2$, where
 $C_{\lambda,\gamma_j}'=\frac{1}{\lambda+1}C_{\lambda+1,\gamma_j}$,
 $j=1,2$.
Then
\begin{equation}\label{45}
-\int_0^{T}( D_{_{0_+}}^{\gamma_1}\psi(t))f(u(t),v(t)) dt
=\int_0^{T}C_{\lambda,\gamma_1}'\phi(t)(T-t)^{ 1-\gamma_1}f(u(t),v(t)) dt.
\end{equation}

From  \eqref{42}, \eqref{43} and \eqref{45} and since $u_0$ is positive and
 $\phi$ is in $C^{1}([0,T])$, thanks to \eqref{41},  an integration by parts
yields
\begin{equation}\label{46}
\begin{aligned}
&C_{\lambda,\gamma_1}'\int_0^{T}\phi(t)(T-t)^{ 1-\gamma_1}f(u(t),v(t)) dt\\
&\leq-\int_0^{T} u(t)\phi'(t) dt + \sum_{i=1}^{n}
 \int_0^{T} u(t)D^{\alpha_i}_{T_{-}} (	a_{i} \phi(t)) dt.
\end{aligned}
\end{equation}
Observe that if \ $p{'}$ is the conjugate of \ $p$, then
\begin{equation}\label{47}
\begin{aligned}
&\int_0^{T} u(t) (-\phi'(t)) dt\\
&=  \int_0^{T}  u(t) ( \phi (t)) ^{\frac{1}{p}} ( \phi(t)) ^{-1/p}
 (T-t)^\frac{{ 1-\gamma_2}}{p}(T-t)^\frac{ -(1-\gamma_2)}{p}(- \phi'(t)) dt \\
&\leq  C_{\lambda,\gamma_2}'\frac{b}{4} \int_0^{T} |  u(t)| ^{p}
     \phi(t)(T-t)^{1-\gamma_2} \,dt  \\
&\quad + \Big(\frac{4}{bC_{\lambda,\gamma_2}'}\Big) ^{p'/p}
\int_0^{T} ( \phi(t) )^{-p'/p} (T-t)^{-(1-\gamma_2)\frac{p{'}}{p}}
 | (\phi'(t)) | ^{p'}  dt \\
&\leq C_{\lambda,\gamma_2}'\frac{1}{4 } \int_0^{T} g(u(t),v(t))\phi(t)
 (T-t)^{1-\gamma_2} dt  \\
&\quad +  \Big(\frac{4}{b C_{\lambda,\gamma_2}'}\Big) ^{p'/p}
\int_0^{T}  (\phi(t) ) ^{-p'/p}(T-t)^{-(1-\gamma_2)\frac{p{'}}{p}}
 | \phi'(t)| ^{p'}  dt,
\end{aligned}
\end{equation}
and for all $ 1\leq i \leq n$,
\begin{equation}\label{48}
\begin{aligned}
&\int_0^{T} u(t)  (D^{\alpha_i}_{T_{-}} (a_{i} \phi(t) )dt \\
&= \int_0^{T} u (t)( \phi(t) )^{\frac{1}{p}}    (\phi(t) ) ^{-\frac{1}{p}}
 (T-t)^\frac{{ 1-\gamma_2}}{p}(T-t)^\frac{-(1-\gamma_2)}{p}
    D^{\alpha_i}_{T_{-}}( a_{i} \phi(t)) dt  \\
&\leq C_{\lambda,\gamma_2}'\frac{b}{4n} \int_0^{T} | u(t) |^{p}
   \phi(t)(T-t)^{1-\gamma_2}   dt  \\
&\quad + \Big(\frac{4n}{bC_{\lambda,\gamma_2}'}\Big) ^{p'/p} a_{i}^{p'}
\int_0^{T} (\phi(t)) ^{-p'/p}(T-t)^{-(1-\gamma_2)\frac{p{'}}{p}}
| (D^{\alpha_i}_{T_{-}}\phi(t)) | ^{p'}dt \\
&\leq C_{\lambda,\gamma_2}' \frac{1}{4n} \int_0^{T} g(u(t),v(t))
 \phi(t)(T-t)^{1-\gamma_2} dt \\
&\quad + \Big( \frac{4n}{bC_{\lambda,\gamma_2}'}\Big) ^{p'/p}
\bar{a}^{p'}\int_0^{T} (\phi(t)) ^{-p'/p}(T-t)
^{-(1-\gamma_2)p'/p} | (D^{\alpha_i}_{T_{-}}\phi(t)) | ^{p'}dt.
\end{aligned}
\end{equation}
Furthermore,
\begin{equation}\label{49}
\begin{aligned}
&C_{\lambda,\gamma_1}'\int_0^{T}f(u(t),v(t)) \phi(t)(T-t)^{1-\gamma_1}dt \\
&\leq \frac{1}{2} C_{\lambda,\gamma_2}'\int_0^{T} g(u(t),v(t))
 \phi(t)(T-t)^{1-\gamma_2}\,dt \\
&\quad + \Big(\frac{4}{bC_{\lambda,\gamma_2}'}\Big) ^{p'/p}
 \int_0^{T} ( \phi(t) ) ^{-p'/p}
   (T-t)^{-(1-\gamma_2)\frac{p{'}}{p}} |  \phi'(t) | ^{p'} dt  \\
&\quad + \bar{a}^{p'}\Big( \frac{4n}{bC_{\lambda,\gamma_2}'}\Big) ^{p'/p}
 \sum_{i=1}^{n}  \int_0^{T} ( \phi(t) ) ^{-p'/p}
(T-t)^{-(1-\gamma_2)\frac{p{'}}{p}} \ | D^{\alpha_i}_{T_{-}}\phi(t)) | ^{p'}dt.
\end{aligned}
\end{equation}
Analogously, if $q'$ is the conjugate of $q$, we obtain
\begin{equation}\label{410}
\begin{aligned}
&C_{\lambda,\gamma_2}'\int_0^{T} g(u(t),v(t)) \phi(t)(T-t)^{1-\gamma_2} dt  \\
&\leq -\int_0^{T} v(t)\phi'(t) dt + \sum_{i=1}^{n}\int_0^{T}  v(t)
 D^{\beta_i}_{T_{-}} ( \ b_{i}(t)\phi(t) ) dt \\
&\leq \frac{1}{2  }  C_{\lambda,\gamma_1}'\int_0^{T} f(u(t),v(t))
  \phi(t)(T-t)^{1-\gamma_1} dt  \\
&\quad + \Big( \frac{4}{aC_{\lambda,\gamma_1}'}\Big) ^{q'/q}
 \int_0^{T} ( \phi(t) ) ^{-q'/q}(T-t)^{-(1-\gamma_1)q'/q}
 | \phi'(t) | ^{q'} dt \\
&\quad +  \bar{b}^{q'}\Big( \frac{4n}{aC_{\lambda,\gamma_1}'}\Big) ^{q'/q}
\sum_{i=1}^{n}  \int_0^{T} ( \phi(t) ) ^{-q'/q}
(T-t)^{-(1-\gamma_1)q'/q} | D^{\beta_i}_{T-}\phi(t)|^{q'}dt.
\end{aligned}
\end{equation}
Denote
\begin{gather*}
A := C_{\lambda,\gamma_1}'\int_0^{T} f(u(t),v(t)) \phi(t) (T-t)^{1-\gamma_1} dt,\\
B : = C_{\lambda,\gamma_2}'\int_ {0}^{T} g(u(t),v(t)) \phi(t) (T-t)^{1-\gamma_2}
 dt, \\
C : = \int_0^{T}( \phi(t) ) ^{-p'/p} (T-t)^{-(1-\gamma_2)\frac{p'}{p}}
 | \phi'(t) \ | ^{p'} dt, \\
D := \int_0^{T} ( \phi(t) )^{-q'/q}(T-t)^{-(1-\gamma_1)q'/q}
  | \phi'(t) | ^{q'} dt,  \\
 E : =  \int_0^{T} ( \phi(t) ) ^{-p'/p}(T-t)^{-(1-\gamma_2)\frac{p'}{p}}
  \sum_{i=1}^{n} | D^{\alpha_i}_{T-}\phi(t) | ^{p'}dt,\\
F := \int_0^{T} ( \phi(t) ) ^{-q'/q}(T-t)^{-(1-\gamma_1)q'/q}
  \sum_{i=1}^{n} |  D^{\beta_i }_{T-}\phi(t)| ^{q'} dt.
\end{gather*}
From \eqref{49} and \eqref{410} we have
\begin{gather*}
A \leq \frac{1}{2} B + \Big( \frac{4}{bC_{\lambda,\gamma_2}'}\Big) ^{p'/p}
 (C+ n^{p'/p}\bar{a}^{p'}E), \\
B \leq \frac{1}{2} A+ \Big( \frac{4}{aC_{\lambda,\gamma_1}'}\Big) ^{q'/q}
 (D+ n^{q'/q}\bar{b}^{q'}F),
\end{gather*}
then
\begin{align*}
A&\leq  \frac{1}{2} \Big(  \frac{1}{2} A
 + \Big( \frac{4}{aC_{\lambda,\gamma_1}'}\Big) ^{q'/q}
 (D+ n^{q'/q}\bar{b}^{q'}F)\Big)
 + \Big( \frac{4}{bC_{\lambda,\gamma_2}'}\Big) ^{p'/p}
 (C+n^\frac{p'}{p} \bar{a}^{p'}E) \\
&= \frac{1}{4 } A + \frac{1}{2}
\Big( \frac{4}{aC_{\lambda,\gamma_1}'}\Big) ^{q'/q}(D+n^{q'/q}\bar{b}^{q'}F)
 +\Big( \frac{4}{bC_{\lambda,\gamma_2}'}\Big) ^{p'/p}
 (C+n^\frac{p'}{p}\bar{a}^{p'}E);
\end{align*}
thus
\[
A\leq  \frac{2}{3} \Big( \frac{4}{aC_{\lambda,\gamma_1}'}\Big) ^{q'/q}
 (D+ n^{q'/q}\bar{b}^{q'}F) + \frac{4}{3}
\Big( \frac{4}{bC_{\lambda,\gamma_2}'}\Big) ^{p'/p}
 (C+ n^\frac{p'}{p}\bar{a}^{p'}E)
\]
and
\begin{align*}
B&\leq \frac{1}{2}  \Big( \frac{2}{3} \Big( \frac{4}{aC_{\lambda,\gamma_1}'}
 \Big) ^{q'/q}(D+ n^{q'/q}\bar{b}^{q'}F)
  + \frac{4}{3}\Big( \frac{4}{bC_{\lambda,\gamma_2}'}\Big) ^{p'/p}
 (C+n^\frac{p'}{p} \bar{a}^{p'}E) \Big)  \\
&\quad + \Big( \frac{4}{aC_{\lambda,\gamma_1}'}\Big) ^{q'/q}
 (D+ n^{q'/q}\bar{b}^{q'}F)\\
&\leq \frac{4}{3} \Big( \frac{4}{aC_{\lambda,\gamma_1}'}\Big) ^{q'/q}
 (D+n^{q'/q}\bar{b}^{q'}F) + \frac{2}{3} \Big( \frac{4}{bC_{\lambda,\gamma_2}'}
 \Big) ^{p'/p}   ( C +n^\frac{p'}{p}\bar{a}^{p'}E ).
\end{align*}

Taking into account  \eqref{42}, \eqref{47} and \eqref{48}, we deduce that
\begin{align*}
&u_0 \int_0^{T} D^{\alpha_1}_{T_{-}} \phi(t) dt \\
&=   \frac{u_0 }{a_1}  \int_0^{T} D^{\alpha_1}_{T_{-}}  (a_1\phi(t) ) dt \\
&\leq   \frac{ 1}{a_1} \Big( -\int_0^{T} u(t) \ \phi'(t) dt
 + \int_0^{T} \sum_{i=1}^{n}u(t) \ D^{\alpha_i}_{T_{-}} (a_{i}\phi(t)) \,dt
  \Big) \\
&\leq   \frac{ 1}{ a_1} \Big( \frac{1}{2}B
 +\Big( \frac{4}{bC_{\lambda,\gamma_2}'}\Big) ^{p'/p}
 (C+  n^\frac{p'}{p}\bar{a}^{p'}E)\Big)  \\
&\leq  \frac{1}{a_1} \Big( \frac{2}{3} \Big( \frac{4}{aC_{\lambda,\gamma_1}'}
\Big) ^{q'/q} (D + n^{q'/q}\bar{b}^{q'} F )
+ \frac{4}{3} \Big( \frac{4}{bC_{\lambda,\gamma_2}'}\Big) ^{p'/p}
 (C+ n^\frac{p'}{p}\bar{a}^{p'}E)\Big) .
\end{align*}
For $ \lambda>\max\{\frac{p'}{p}+p{'}-1, \frac{q'}{q}+q{'}-1\} $,  it holds
\begin{equation} \label{411}
\int_0^{T} D^{\alpha_i}_{T_{-}} \phi(t)dt
= C_{\alpha_i,\lambda} T^{1-\alpha_i},
\end{equation}
 where 
\[
  C_{\alpha_i,\lambda}= \frac{\Gamma(\lambda+1)}{\Gamma(\lambda - \alpha_i +2)},
 \quad \forall 1\leq i \leq n\,.
\]
Also there exists a positive constant $K$ such that
\begin{gather}
C \leq K T^{(\gamma_2-1)\frac{p'}{p}+1-p'}, \quad
D \leq K T^{(\gamma_1-1)\frac{q'}{q}+1-q'}, \nonumber\\
\label{412}
E\leq K \sum_{i=1}^{n}T^{(\gamma_2-1)\frac{p{'}}{p}+1-p' \alpha_i}, \quad
F\leq K \sum_{i=1}^{n}T^{(\gamma_1-1)\frac{q{'}}{q}+1-q'\beta_i}, \quad
\forall 1\leq i \leq n.
\end{gather}
Consequently,
\begin{equation}\label{413}
\begin{aligned}
&u_0 \int_0^{T}D^{\alpha_1}_{T_{-}}\phi(t) dt \\
&\leq \frac{ 2}{3 a_1} \Big( \frac{4}{aC_{\lambda,\gamma_1}'}\Big) ^{q'/q}
K\Big(   T^{(\gamma_1-1)\frac{q'}{q}+1-q'}
+n^{q'/q}\bar{b}^{q'}\sum_{i=1}^{n} T^{(\gamma_1-1)\frac{q{'}}{q}+1-q'\beta_i}\Big)  \\
&\quad + \frac{4}{3a_1}\Big( \frac{4}{bC_{\lambda,\gamma_2}'}\Big) ^{p'/p
}K\Big(  T^{(\gamma_2-1)\frac{p'}{p}+1-p'} +
  n^\frac{p'}{p}\bar{a}^{p'}\sum_{i=1}^{n} T^{(\gamma_2-1)\frac{p{'}}{p}
+1-p' \alpha_i}\Big).
\end{aligned}
\end{equation}
Using \eqref{411} and \eqref{413}, we obtain
\begin{equation}\label{414}
\begin{aligned}
u_0  &\leq    C_{\alpha_1, \lambda}^{-1}K \Big\{
\frac{ 2}{3 a_1} \Big( \frac{4}{aC_{\lambda,\gamma_1}'}\Big) ^{q'/q}
 \Big(  T^{(\gamma_1-1)\frac{q'}{q}+\alpha_1-q'} \\
&\quad +n^{q'/q}\bar{b}^{q'}\sum_{i=1}^{n} T^{(\gamma_1-1)
 \frac{q{'}}{q}+\alpha_1-q'\beta_i}\Big) \Big\}  \\
&\quad + C_{\alpha_1, \lambda}^{-1}K\Big\{ \frac{4}{3a_1}
 \Big( \frac{4}{bC_{\lambda,\gamma_1}'}\Big) ^{p'/p}
 \Big(  T^{(\gamma_2-1)\frac{p'}{p}+\alpha_1-p' }\\
&\quad  +n^\frac{p'}{p}\bar{a}^{p'}\sum_{i=1}^{n}
  T^{(\gamma_2-1)\frac{p{'}}{p}+\alpha_1-p' \alpha_i}\Big) \Big\}.
\end{aligned}
\end{equation}
Similarly  we obtain
 \begin{align*}
&v_0 \int_0^{T}D^{\beta_1}_{T_{-}}\phi(t) dt \\
&\leq  \frac{1}{b_1}\Big( \frac{1}{2}A
 + \Big( \frac{4}{aC_{\lambda,\gamma_1}'}\Big) ^{q'/q}(D +n^{q'/q}\bar{b}^{q'}F)\Big)
  \\
&\leq  C_{\beta, \lambda}^{-1}\Big(  \frac{4}{3b_1}
 \Big( \frac{4}{aC_{\lambda,\gamma_1}'}\Big) ^{q'/q}( D + n^{q'/q}\bar{b}^{q'} F )
 + \frac{2}{3 b_1} \Big( \frac{4}{bC_{\lambda,\gamma_2}'}\Big)^{p'/p}
(C+ n^\frac{p'}{p}\bar{a}^{p'} E)\Big) ,
\end{align*}
which yields
\begin{equation}\label{415}
\begin{aligned}
v_0  &\leq  C_{\beta_1, \lambda}^{-1}K\Big\{  \frac{4}{3b_1}
\Big( \frac{4}{aC_{\lambda,\gamma_1}'}\Big) ^{q'/q}
\Big(  T^{(\gamma_1-1)\frac{q'}{q}+\beta_1-q'} \\
&\quad +  n^{q'/q}{\bar{b}^{q'}}
 \sum_ {i=1}^{n}   T^{(\gamma_1-1)\frac{q{'}}{q}+\beta_1-q'\beta_i}\Big) \Big\}  \\
&\quad + C_{\beta_1, \lambda}^{-1}K\Big\{ \frac{2}{3b_1}
 \Big( \frac{4}{bC_{\lambda,\gamma_2}'}\Big) ^{p'/p}
 \Big(   T^{(\gamma_2-1)\frac{p'}{p}+\beta_1-p'}\\
&\quad + n^\frac{p'}{p}\bar{a}^{p'} \sum_{i=1}^{n} T^{(\gamma_2-1)\frac{p{'}}{p}
 +\beta_1-p' \alpha_i}\Big) \Big\}.
\end{aligned}
\end{equation}
One can observe that
\begin{equation}\label{416}
\begin{gathered}
(\gamma_1-1)\frac{q'}{q}+\alpha_1-q'<0,\quad (\gamma_2-1)\frac{p'}{p}+\alpha_1-p'<0, \\
(\gamma_1-1)\frac{q'}{q}+\beta_1-q'<0, \quad (\gamma_2-1)\frac{p'}{p}+\beta_1-p'<0,\\
(\gamma_2-1)\frac{p'}{p}+\alpha_1-p'\alpha_i<0,\quad
(\gamma_1-1)\frac{q{'}}{q}+\beta_1-q'\beta_i<0,\quad \forall 1\leq i\leq n, \\
(\gamma_2-1)\frac{p{'}}{p}+\beta_1-p' \alpha_i<\beta_1-\alpha_1,   \quad
(\gamma_1-1)\frac{q'}{q}+\alpha_1-q'\beta_i<\alpha_1-\beta_1,\\
\forall 1\leq i\leq n.
\end{gathered}
 \end{equation}
 Inequalities \eqref{416} reduce to
\[
(\gamma_2-1)\frac{p{'}}{p}+\beta_1-p' \alpha_i<0,\quad \forall 1\leq i\leq n,
\]
or
\[
(\gamma_1-1)\frac{q'}{q}+\alpha_1-q'\beta_i<0,\quad \forall  1\leq i\leq n.
\]
Taking the limit when $T$ approaches infinity in \eqref{414} and \eqref{415},
we find
\begin{equation}
 0<u_0 \leq 0 \quad \text{or} \quad \  0<v_0\leq 0 .
\end{equation}
This leads to a contradiction and consequently the maximal
time of existence for the solution to \eqref{11}-\eqref{12}
is finite and this completes the proof.
\end{proof}

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\end{document}
